Covid, braking on the fourth dose: that’s why

Children and very young people receive the anti Covid vaccine in Naples (Ansa)

Braking in view of the booster policy to the bitter end. The third dose is proving to be providential, also effective on the Omicron variant. But a fourth blow for everyone in a short time, nowadays, seems an unthinkable prospect. So, what will happen in a few months, when the first who underwent the third recall (ie those who did it before Christmas) will see the Green pass expire? Let’s think about it. Change of course WHO and the European Medicines Agency (EMA) have hinted at a change of course. Super experts say recalling millions of people with vaccines still calibrated for the Wuhan virus at almost every change of season would be a logistically unsustainable undertaking. Also from the point of …

Braking in view of the booster policy to the bitter end. There third dose it is proving to be providential, effective also on the variante Omicron. But one fourth hit for everyone in a short time, today as today, it seems an unthinkable prospect. So, what will happen in a few months, when the first who underwent the third recall (i.e. those who did it before Christmas) will see the Green pass expires? Let’s think about it.

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Route change

L‘WHO and the European Medicines Agency (Ema) they hinted at a change of course. Super experts say recalling millions of people with vaccines still calibrated for the Wuhan virus at almost every change of season would be a logistically unsustainable undertaking. Even from a clinical point of view, certainties end with the third dose. “We cannot proceed with boosters every 3-4 months – said Marco Cavaleri, number one of the EMA vaccination strategy – data on the fourth dose are still lacking, a strategy that plans to go ahead with vaccinations in a short time is worrying.” Obviously when it comes to vulnerable people it is a different case. The fourth dose could perhaps benefit immunosuppressed individuals, commented Akiko Iwasaki, an immunologist at Yale, interviewed by the New York Times, but subjecting the entire population to boosters after a few months seems unrealistic. “We must obtain long-lasting vaccines, also intended for low-income countries – remarked the microbiologist Andrea Crisanti – but it sounds impossible to vaccinate 50 million people every 4 months”.

When is the anti-Omicron vaccine?

“It is extremely unlikely, if not impossible, to think of being able to eradicate Covid,” said immunologist Anthony Fauci, in video link with Sapienza, University of Rome. “We must try to control this phenomenon without paralyzing society – added the advisor for the pandemic of the president of the United States – as already happens with the flu and other respiratory diseases with which we have learned to live. We are probably going to that. direction, but now in the United States, with a million cases a day, we are not there yet. ” At the end of January, the contagion curve will drop. Now the question is: how are we going to get back to normal life? To do this, it is necessary to take into account those lethal complications that until a couple of years ago were caused by the most challenging flu syndromes, pneumonia, meningitis, and nosocomial infections caused by antibiotic-resistant bacteria. A silent massacre that few pay attention to. Waiting for the news (Novavax and Valneva) today everyone knows the usefulness of antivirals (molnupiravir, remdesivir) to be administered at the first symptoms. And if the pharmaceutical industry comes out with a new anti Covid product updated to the Omicron variant by March, things could perhaps take another turn. Theoretically, an approval for the latter by the EMA could arrive in April or May, but for now there is no news on the matter.

The response of the immune system

Months of hammering have generated a pessimism from which it is difficult to escape. While in Israel the fourth doses of anti-Covid are administered to fragile subjects, among American scientists there are those who foreshadow the risk of weakening the immune system, a sort of antigenic original sin, arguing that leaving a greater time interval between doses could even strengthen the natural defenses. On Covid, everyone would like to have their say, no one has the truth in their pocket. Public opinion appears tired of impositions. Most have understood that it will be difficult to evict the virus: we will have, with the right precautions, to learn to live with it.

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